misfire on #4 and #6 cylinder. 4.7

P0300 DODGE - Cylinder Misfire Fault Detected Random Cylinders...Possible causes Faulty spark plug (s), Faulty ignition coil (s), Clogged or faulty fuel injector (s), Intake air leak, Fuel injectors harness is open or shorted, Fuel Injectors circuit poor electrical connection, Ignition coils harness is open or shorted, Ignition coils circuit poor electrical connection, Insufficient cylinders compression, Incorrect fuel pressure...This means that a cylinder(s) is misfiring or is randomly misfiring. Start by checking for intake leaks, intake gaskets are common caused of multi-cylinder misfiring. If no leak are found the next step is to replace the spark plugs. If the problem persist more tests needs to be done to diagnose problem.

changed plugs, coils, injectors, head gasket, had head cleaned and machined. good compression. Could the computer be an issue since it's only on 2 cylinders thats beside each other

Check the compression in those 2 cylinders since they are side by side. Suspect a problem there. Since you have done head work check also that the rocker arms are opening the valves.